NIH Publication No. What does naphthalene do to humans? What color is naphthalene? Those with glucose-6-phosphate dehydrogenase (G6PD) deficiency are especially susceptible. [citation needed] Naphthalene was introduced in 1841 by Rossbach as an antiseptic to counteract typhoid fever.Although naphthalene was widely used industrially, only nine cases of poisoning have been reported since 1947 as of 1956 . If you or someone you are with has an exposure, call your local . Naphthalene 91-20-3 Hazard Summary Naphthalene is used in the production of phthalic anhydride; it is also used in mothballs.
Naphthalene Technical Fact Sheet - Oregon State University DESIGNATION OF NAPHTHALENE AS A CARCINOGEN: RISK ASSESSMENT FOR INHALATION EXPOSURE PATHWAYS AT HAZARDOUS WASTE SITES J P Christopher, B K Davis, J M Polisini, and M J Wade, California Department of Toxic Substances Control, Sacramento Presented at: 44th Annual Meeting of the Society of Toxicology New Orleans, Louisiana 10 March 2005 Naphthalene causes lung toxicity in mice, but not rats, following either intraperitoneal injection or inhalation exposure. Though it is freely available around this country, poisoning has never been reported in the literature. Terminal Body Weights in Controls and in Fischer 344 Rats Exposed to Naphthalene by Gavage for 13 Weeks 7-8 Table 7-2. .
Metabolism and Lung Toxicity of Inhaled Naphthalene: Effects of Naphthalene - Occupational Exposures - CAREX Canada Acute Toxicity 3.3.1.1. Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. The most reliable human data available come from a controlled skin exposure study, but the inhalation PBPK model does not include a skin exposure route; therefore, we extended the model . Naphthalene has been detected in untreated ambient ground water samples.
Naphthalene poisoning - Wikipedia Introduction Naphthalene is commonly found in moth repellent products such as mothballs in developing countries.
First Aid for Naphthalene Poisoning - DoveMed This is because it is a known carcinogen that can bind to DNA and cause mutations that lead to cancer .
What is naphthalene in chemistry? - vanjava.norushcharge.com In mice, the injury is dose-dependent and Clara cell-specific. This article is for information only. In humans, the inhalation of naphthalene vapor causes headache, loss of appetite, and nausea (Flury and Zernik 1931g/Ex. Naphthalene is a white solid substance with a strong smell. A 33-year-old Sri Lankan woman presented to us 2 days . This can cause organ damage.
Naphthalene Toxicity: Methemoglobinemia and Acute Intravascular (APF = 10) Any air-purifying half-mask respirator with organic vapor cartridge (s) in combination with an N95, R95, or P95 filter. View complete answer on epa.gov. Acute (short- term) exposure of humans to naphthalene by inhalation, ingestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage. See annual publication for most recent information. 1-3, p. 420 . This can cause organ damage. tonga volcano eruption again biomedical science jobs san diego 813-731-9283 Looking for a Shuttle in the Tampa Bay Area? Naphthalene has been found in wastewater treatment plant discharge.
1988 OSHA PEL Project - Naphthalene | NIOSH | CDC To The common manifestations are confusion, restlessness, delirium, and hallucinations, muscle twitching, myoclonus, ataxia, hyperreflexia, fasciculations, and seizures. Diarrhea. 3.3. OSHA's former exposure limit for naphthalene was 10 ppm as an 8-hour TWA.
Naphthalene General Fact Sheet - Oregon State University PDF Health Effects Support Document for Naphthalene, February 2003. - US EPA Naphthalene (NA) was shown to be carcinogenic, causing respiratory epithelial adenoma in the nasal cavity of male F344 rats and olfactory epithelial neuroblastoma in female F344 rats at exposure concentrations of 10-60 ppm in a 2-year inhalation study conducted by the National Toxicology Program. Acute lung toxicity and carcinogenesis are thought to be related because the target sites for both are similar. The most likely source of exposure to significant amounts of naphthalene is occupational inhalation of the vapour, since its principal use is in industry [1]. Naphthalene (mothball) is a commonly used deodorizer in the Indian subcontinent, including Sri Lanka. It is best known as the main ingredient of traditional mothballs
The Effects of Inhaling Moth Balls - SportsRec Where can naphthalene be found? Explained by FAQ Blog Acute (short-term) exposure of humans to naphthalene by inhalation, ingestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage. 22 Rats, however, were unaffected following inhalation exposure to naphthalene for four hours . As an aromatic hydrocarbon, naphthalene's structure consists of a fused pair of benzene rings. Classied as a Group C, possible human carcinogen. Coughing, wheezing and shortness of breath are all common side effects of moth ball inhalation. Ingestion, either accidental or by deliberate self-harm, can occur due to its abundance as well as its candy-resembling appearance. If you or someone you are with has an exposure, call your local . Exposure to Naphthalene in Media Other than Water 5-8 Table 7-1. However, the general public may be exposed to naphthalene through inhalation of smoke from burning fossil fuels or wood, or from inhaling vehicle exhaust fumes. Camphor poisoning is not very common in childhood.
Naphthalene: general information - GOV.UK It can also be deposited on plant leaves from the air. OTHER ROUTES OF EXPOSURE 3.3.1. Naphthalene is a white solid substance with a strong smell. Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. DO NOT use it to treat or manage an actual poison exposure. Naphthalene Methemoglobinemia Hemolytic anemia Metabolic acidosis Seizures 1. Naphthalene is toxic to humans through ingestion or inhalation. (APF = 50) Any air-purifying full-facepiece respirator equipped . 1-995; Patty 1949b, as cited in ACGIH 1986/Ex.
Health Effects of Naphthalene Exposure: A Systematic Evidence Map and Acute exposure to naphthalene by inhalation, in-gestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage.
Where can naphthalene be found? - sitillc.dixiesewing.com PDF Naphthalene - US EPA Environmental Eects: Moderate to low mobility in soil. This article is for information only. Naphthalene is a white solid substance with a strong smell. The . Naphthalene, a volatile organic compound found in moth repellants and petroleum-based fuels, has been shown to induce respiratory tract toxicity in both mice and rats during chronic inhalation exposures (NTP, 1992, 2000).Two-year inhalation studies demonstrated carcinogenicity in the form of increased incidence of nasal respiratory epithelium adenomas in male rats and olfactory epithelial . The final rule retains this TWA and adds a short-term limit of 15 ppm for this substance . A published inhalation PBPK model for naphthalene was previously shown to predict rodent PK data well, so we sought to evaluate this model using human PK data. Human exposure to naphthalene (NA), an acute lung toxicant and possible human carcinogen, is primarily through inhalation.
Naphthalene poisoning Information | Mount Sinai - New York NA inhalation exposure induces the expression of several genes or pathways related to lung tumor .
CDC - NIOSH Pocket Guide to Chemical Hazards - Naphthalene The prognosis of Naphthalene Poisoning is dependent on the amount of substance consumed, time between exposure and treatment, severity of the symptoms, as well as general health status of the patient If the individual can recover from the symptoms, with appropriate medication and prompt medical support, the outcome can be good. 21 Clara cells are nonciliated bronchiolar cells containing P450 enzymes, the makeup and distribution of which are species dependent. Naphthalene poisoning is a rare form of toxicity that may occur after ingestion, inhalation, or dermal exposure to naphthalene-containing compounds such as mothballs.
Kerosene, Camphor, and Naphthalene Poisoning in Children Clinically, patients present with acute onset of dark brown urine, watery diarrhea, and non-bloody bilious vomiting 48-96 hours after exposure. Click here for information on selection of N, R, or P filters.*. 92-3141.
A Physiologically Based Pharmacokinetic Model for Naphthalene With Humans, particularly children, have developed hemolytic anemia after ingesting mothballs or deodorant blocks containing naphthalene. A reference concentration (RfC) for inhalation exposure to naphthalene has not been derived (U.S. EPA, 1991, 1992). Exposed to Naphthalene by Inhalation for Their Lifetime 7-15 Table 7-4. from mothballs). Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. Naphthalene is generally white in color. DO NOT use it to treat or manage an actual poison exposure. Cataracts have also been reported in .
PDF C hemicalWatch Factsheet - Beyond Pesticides The following filters may also be used: N99, R99, P99, N100, R100, P100. Use of naphthalene balls as chronic inhalant abuse was however reported by Weintraub et al., which was associated with chronic neuropathy and chronic renal failure.
Acute naphthalene toxicity presenting with metabolic acidosis: a rare 410. Exposure to naphthalene. (1992). Diarrhea can indicate naphthalene poisoning. Severe poisoning can result in haemolytic anaemia. This can cause organ damage. DO NOT use it to treat or manage an actual poison exposure. The onset of action is very rapid (5-15 minutes). Naphthalene is broken down by bacteria, fungi, air, and sunlight. NIOSH/OSHA. Acute exposure can even lead to temporary blindness or cataracts.
NAPHTHALENE | Occupational Safety and Health Administration Human. Headache, nausea, vomiting, abdominal cramps . from incomplete combustion) and/or indoor air (i.e. Hemolytic anemia and methemoglobinemia are . Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. Long-term exposure to low levels of naphthalene may increase your risk of developing cancer.
Nasal epithelial lesions in F344 rats following a 90-day inhalation A Physiologically Based Pharmacokinetic Model for Naphthalene With NAPHTHALENE (IARC Summary & Evaluation, Volume 82, 2002) . NTP: Toxicology and carcinogenesis studies of naphthalene in B6C3F1 mice (inhalation studies). Technical Report Series No. Naphthalene is a primary irritant upon direct skin contact and may be acutely irritating to the eyes.
Acute intravascular hemolysis due to naphthalene toxicity: a case Symptoms of naphthalene poisoning include headache, dizziness, nausea, and fatigue.
Naphthalene poisoning | UF Health, University of Florida Health Naphthalene Poisoning. Exposure to large amounts of naphthalene may damage or destroy red blood cells. Accidental or intentional poisoning by naphthalene has been reported by swallowing, skin contact, and inhalation. Exposure to naphthalene commonly causes headache, nausea, vomiting, diarrhea, abdominal pain, fever, and altered mental status. Acute (short- term) exposure of humans to naphthalene by inhalation, ingestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage. Naphthalene is a polycyclic aromatic hydrocarbon (PAH), but exposure here is intended to .
PDF Designation Of Naphthalene As A Carcinogen: Risk Assessment For Naphthalene is an organic compound with formula C 10 H 8.It is the simplest polycyclic aromatic hydrocarbon, and is a white crystalline solid with a characteristic odor that is detectable at concentrations as low as 0.08 ppm by mass. Naphthalene poisoning (or mothball poisoning) is a form of poisoning that occurs when naphthalene is ingested. Vital sign abnormalities include . Incidence and Severity of Nonneoplastic Lesions in the Noses of Rats in a After repeated administration of naphthalene, mouse Clara cells become tolerant to the naphthalene-induced injury that occurs following a single dose of . Naphthalene inhalation exposure is well known to produce respiratory lesions, so lack of reported blinding was flagged as a potential concern in studies .
Naphthalene Poisoning During a Decade: A Retrospective Clinical Study Illness Associated with Exposure to Naphthalene in Mothballs -- Indiana